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HLA typing does not predict REM sleep behaviour disorder and hallucinations in Parkinson's disease
Marco Onofrj1, Anna Lisa Luciano1, Diego Iacono1
1Department of Oncology and Neuroscience, Movement Disorders Center, Neurophysiopathology, Università G. D'Annunzio, Chieti-Pescara, Italy.
Abstract:
HLA-DR2 haplotype and DQ1 DNA alleles, characterizing 90 to 100% of all narcoleptic patients, were found to be equally distributed in 20 Parkinson's disease (PD) patients with early hallucinations, rapid eye movement (REM) sleep-related behaviour disturbances (RBD), and sleep onset in REM (SOREM), and in 20 PD patients without hallucinations, despite 10 to 15 years of treatment, and no RBD or SOREM.