Related Experiment Video

Updated: Aug 8, 2026

Organotypic Culture of Adult Rabbit Retina
10:12

Organotypic Culture of Adult Rabbit Retina

Published on: April 29, 2007

Organic cation uptake in vitro by the rabbit iris-ciliary body, renal cortex, and choroid plexus

E H Bárány

    Investigative Ophthalmology
    |May 1, 1976
    PubMed

    More Related Videos

    Measuring Cation Transport by Na,K- and H,K-ATPase in Xenopus Oocytes by Atomic Absorption Spectrophotometry: An Alternative to Radioisotope Assays12:48

    Measuring Cation Transport by Na,K- and H,K-ATPase in Xenopus Oocytes by Atomic Absorption Spectrophotometry: An Alternative to Radioisotope Assays

    Published on: February 19, 2013

    Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs10:02

    Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs

    Published on: July 23, 2016

    Related Concept Videos

    Drug Elimination by Renal Route: Tubular Reabsorption01:22

    Drug Elimination by Renal Route: Tubular Reabsorption

    During the process of renal excretion, as the glomerular filtrate progresses to the distal convoluted tubule (DCT), drugs that are highly permeable, lipophilic, and nonionized undergo passive reabsorption from the tubular fluid into the surrounding peritubular capillaries. This reabsorption process restricts their elimination through the kidneys. However, the majority of drugs are either weak acids or weak bases, and their ionization level is dependent on pH. By altering the pH of urine, the...
    Drug Elimination by Renal Route: Tubular Secretion01:15

    Drug Elimination by Renal Route: Tubular Secretion

    Once the process of glomerular filtration is completed, blood carrying unfiltered drug molecules traverses through efferent arterioles and makes its way into the peritubular capillaries in the proximal tubule. A variety of carriers play a pivotal role in actively secreting drugs from these peritubular capillaries into the tubular fluid. The organic anion transporter transfers acidic drugs, against an electrochemical gradient, from the peritubular capillaries into the renal tubule cells and...
    Reabsorption and Secretion in the PCT01:28

    Reabsorption and Secretion in the PCT

    The Proximal Convoluted Tubule, or PCT, plays a pivotal role in the body's filtration system. They are primarily responsible for reabsorbing solutes and water from the filtered fluid produced by the glomeruli. Most of the filtered water, ions, and organic solutes such as glucose and amino acids are reabsorbed by the PCT.
    Transport mechanisms involving sodium ions (Na+) contribute significantly to solute reabsorption. These mechanisms include symport and antiport processes.
    A key example is the...
    Pore Transport and Ion-Pair Transport01:17

    Pore Transport and Ion-Pair Transport

    Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
    Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct microscopic...
    Methods for Studying Drug Absorption: In vitro01:16

    Methods for Studying Drug Absorption: In vitro

    In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
    The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
    Methods for Studying Drug Absorption: In situ01:09

    Methods for Studying Drug Absorption: In situ

    In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
    The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...