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Comparison of left ventricular ejection fraction and regional contractility fraction pre and post coronary
Insights
Left ventriculography is safe before or after coronary angiography. Evaluating left ventricular function (LVF) parameters like ejection fraction (EF) is reliable, even with contrast material effects in coronary artery disease (CAD) patients.
Area of Science:
- Cardiology
- Medical Imaging
- Diagnostic Procedures
Background:
- Left ventricular function (LVF) assessment is crucial in diagnosing and managing coronary artery disease (CAD).
- Left ventriculography is a key imaging technique for evaluating LVF, but concerns exist regarding contrast material effects.
- The timing of left ventriculography relative to coronary angiography may impact the accuracy of LVF measurements.
Purpose of the Study:
- To evaluate left ventricular function (LVF) parameters before and after coronary angiography.
- To assess the impact of contrast material on normal and diseased myocardial segments.
- To determine if left ventriculography can be safely performed before or after coronary angiography without affecting results.
Main Methods:
- Thirty patients (normals, mild CAD, severe CAD) underwent left ventriculography.
- End diastolic volume (EDV), end systolic volume (ESV), ejection fraction (EF), and regional contractility fractions (RCF) were measured.
- RCFs were analyzed to account for contrast-induced changes in EF.
Main Results:
- Good correlation (r = .45 to .97, p < .01 to < .001) was observed for LVF parameters before and after angiography.
- Contrast material caused transient changes in myocardial contractility.
- No spurious findings in EF were detected due to reciprocal RCF changes.
Conclusions:
- Left ventriculography can be performed before or after coronary angiography without compromising diagnostic accuracy.
- LVF assessment using left ventriculography is reliable in patients with and without CAD, even with contrast administration.
- The study supports the safety and efficacy of sequential angiography procedures.
Abstract:
Thirty patients [four normals, eight with mild and 18 with severe coronary artery disease (CAD)] were studied to evaluate left ventricular function type and post coronary angiography. The end diastolic volume (EDV), end systolic volume (ESV), ejection fraction (EF) and the regional contractility fractions (RCF) of eight ventricular segments were evaluated by left ventriculography. The RCF's were analyzed, in addition to the EF's to ascertain the effect of contrast material upon normal and scarred or ischemic segments of the left ventricle, and to rule out spurious findings in the EF due to coexistent reciprocal changes in RCF's. There was good correlation (r = .45 to .97 and p less than .01 to less than .001) in the above parameters of left ventricular function in patients with and without CAD before and after angiography. Thus, although intraventricular and intracoronary injections of contrast material produce transient changes in myocardial contractility, in a clinical setting left ventriculography may be performed prior to or following coronary angiography without danger of spurious results in normals and in patients with CAD.