Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methotrexate for cervical pregnancy. A case report.

Cetin Celik1, Ayfer Bala, Ali Acar

  • 1Department of Obstetrics and Gynecology, Selçuk University Faculty of Medicine, Akyokuş, 42080 Konya, Turkey. celikcet@hotmail.com

The Journal of Reproductive Medicine
|March 8, 2003
PubMed
Summary

Methotrexate is a safe and effective treatment for cervical pregnancy, a rare form of ectopic pregnancy. This fertility-sparing approach avoids hysterectomy and successfully manages the condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Menopause and epigenetic changes: a review.

Climacteric : the journal of the International Menopause Society·2026
Same author

Insights into the toxic effects of moxifloxacin in Allium cepa through multiparametric experimental and in silico analyses.

Scientific reports·2026
Same author

Linker dependence of <sup>1</sup>O<sub>2</sub> generation by G4-binding tetra-imidazolium porphyrins.

Organic & biomolecular chemistry·2026
Same author

Intravaginal Aloe barbadensis and cervical HPV clearance: A retrospective observational study.

Pakistan journal of pharmaceutical sciences·2026
Same author

Ecological and Ethological Assessment of Captive <i>Testudo graeca</i> in an Urban Bazaar: A Case of High-Constraint Wildlife Tourism in Kastamonu, Northern Anatolia.

Animals : an open access journal from MDPI·2026
Same author

Evaluation of Clitoral Artery Doppler Parameters After Brachytherapy and Its Effects On Sexual Functions.

Journal of lower genital tract disease·2026

Area of Science:

  • Reproductive Medicine
  • Gynecologic Oncology

Background:

  • Cervical pregnancy is a rare form of ectopic pregnancy (<1% of all ectopic gestations) with a high risk of hemorrhage.
  • Traditional management via curettage is often associated with significant bleeding due to the cervix's limited muscularity, potentially necessitating hysterectomy.
  • Nonsurgical management, particularly with methotrexate, offers a viable alternative with high success rates in selected cases.

Observation:

  • A 36-year-old woman presented with vaginal bleeding and lower abdominal pain at 7 weeks gestation.
  • Transvaginal ultrasonography confirmed a cervical pregnancy with the gestational sac implanted in the cervical wall.
  • The patient received an initial dose of 50 mg methotrexate injected directly into the gestational sac, followed by an additional 50 mg intramuscularly.

Findings:

Related Experiment Videos

  • Following methotrexate administration, human chorionic gonadotropin (hCG) levels showed a continuous decline.
  • hCG levels became undetectable within 35 days, indicating successful pregnancy resolution.
  • The patient's condition was managed without surgical intervention or significant complications.

Implications:

  • Local and systemic methotrexate administration is a safe and effective treatment for cervical pregnancy.
  • This medical management strategy preserves fertility, offering a crucial advantage over hysterectomy.
  • Methotrexate represents a key therapeutic option for managing cervical pregnancies, improving patient outcomes and reproductive potential.