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Related Experiment Videos

[Elevated liver values of uncertain origin].

S Lucini1, P Brun, A Gaspert

  • 1Medizinische Poliklinik, Departement für Innere Medizin, Universitätsspital Zürich.

Praxis
|March 8, 2003
PubMed
Summary
This summary is machine-generated.

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Schistosomiasis mansoni, a parasitic disease, can cause elevated liver enzymes and diarrhea. Diagnosis via stool and biopsy, followed by praziquantel treatment, effectively resolved symptoms and normalized liver function.

Area of Science:

  • Hepatology
  • Parasitology
  • Gastroenterology

Background:

  • Elevated liver enzymes in a patient with type 1 diabetes and diarrhea prompted an investigation into the underlying etiology.
  • Standard investigations excluded mechanical biliary obstruction, viral hepatitis, and primary biliary cirrhosis.

Observation:

  • The patient presented with cholestatic enzyme elevation and episodes of mild diarrhea.
  • Microscopic stool examination and colonoscopic biopsy were crucial for diagnosis.

Findings:

  • Schistosomiasis mansoni was diagnosed based on stool microscopy and liver biopsy findings, including portal inflammation and pigmented macrophages.
  • The parasitic disease causes liver injury through the release of schistosome eggs into the portal vein system.

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Implications:

  • Early diagnosis and treatment of schistosomiasis mansoni are essential for preventing progressive liver damage.
  • Praziquantel effectively treated the parasitic infection, leading to symptom resolution and normalization of liver enzymes.