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Related Experiment Videos

White cell count and intensive care unit outcome.

U Waheed1, P Williams, S Brett

  • 1Hammersmith Hospital, London, UK.

Anaesthesia
|March 8, 2003
PubMed
Summary

A low white cell count (leukopenia) on intensive care unit admission indicates a higher mortality risk. Both leukopenia and extremely high white cell counts are linked to increased patient death rates.

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Area of Science:

  • Critical Care Medicine
  • Hematology

Background:

  • A high white cell count in intensive care unit (ICU) patients often signals severe illness.
  • The prognostic implications of a low white cell count (leukopenia) are less understood.

Purpose of the Study:

  • To investigate the association between white cell count on ICU admission and patient mortality.
  • To compare outcomes for patients with leukopenia versus those with normal or elevated white cell counts.

Main Methods:

  • Retrospective analysis of data from 4,165 ICU patients.
  • Categorization of white cell counts into four groups: leukopenic, normal, leukemoid, and exaggerated leukemoid response.

Main Results:

  • Leukopenia (< 4.0 x 10(9)/L) on ICU admission was associated with higher mortality (37.5%) compared to normal (18.9%) or moderately elevated counts (23.9%).

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  • Both leukopenic and exaggerated leukemoid responses (> 25.0 x 10(9)/L) correlated with increased mortality.

    • Conclusions:

    • White cell count on ICU admission is a significant prognostic indicator.
    • Both low and very high white cell counts suggest a poorer patient outcome.