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Phospholipase A2-activating protein--an important regulatory molecule in modulating cyclooxygenase-2 and tumor
Deborah A Ribardo1, Johnny W Peterson, Ashok K Chopra
1Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX 77555-1070, USA.
Indian Journal of Experimental Biology
|March 8, 2003
Abstract:
Inflammation is a complex multifactorial process and a hallmark of many inflammatory diseases. Most of the tissue destruction that occurs in these diseases is the result of an aberrant or often uncontrolled immune response. Factors that play an important role in such diseases include pro-inflammatory cytokines, complement, and eicosanoids. This review focuses on eicosanoids and their regulation via phospholipase A2-activating protein, which could be targeted as a new therapeutic tool to control inflammatory diseases.