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Related Experiment Videos

Variation and immunity to intestinal worms.

D Wakelin1, S E Farias, J E Bradley

  • 1Department of Physiology and Biotechnology Centre, Federal University of Rio Grande do Sul, Brazil. D.Wakelin@nottingham.ac.uk

Parasitology
|March 8, 2003
PubMed
Summary

Parasite genetic variation significantly impacts host immune responses and infection outcomes. Understanding these differences is crucial for developing effective control strategies and predicting host-parasite evolution.

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Area of Science:

  • Parasitology
  • Immunology
  • Evolutionary Biology

Background:

  • Host genetic variation influences resistance to parasites, but parasite variation's role is less understood.
  • Intestinal worm species like Ascaris and trichostrongyles show phenotypic and genotypic variation, yet its impact on host immunity is limited.
  • Experimental models like Strongyloides and Trichinella have limited data on phenotypic or genotypic variation.

Purpose of the Study:

  • To investigate the influence of parasite genotypic variation on host immune responses and infection outcomes.
  • To explore the molecular differences between parasite isolates and their functional consequences.
  • To enhance understanding of host-parasite coevolution and inform control strategies.

Main Methods:

  • Experimental studies using Trichinella genotypes in mice to assess immune and inflammatory responses.

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  • Analysis of Trichuris muris isolates to determine their effect on host T helper cell responses.
  • Molecular characterization of parasite isolates, including excreted/secreted products and DNA.

    • Main Results:

    • Parasite variation significantly influences the type and intensity of host immune and inflammatory responses.
    • Specific Trichuris muris isolates differentially affect the host's capacity for resistance-conferring T helper cell responses.
    • Molecular differences in excreted/secreted products and DNA exist between T. muris isolates.

    Conclusions:

    • Parasite genotypic variation is a critical factor in host-parasite interactions, affecting immune responses and infection dynamics.
    • Understanding parasite variation provides insights into host-parasite evolution and the development of targeted control strategies.
    • Functional consequences of parasite variation can inform predictions for improving host resistance via vaccination or selective breeding.