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Cherubism in siblings: a case report.

Ravikiran Ongole1, Rejeev S Pillai, Keerthilatha M Pai

  • 1Department of Oral Medicine, Diagnosis and Radiology, College of Dental Surgery, Manipal 576119, India. ravikirano@hotmail.com

Journal (Canadian Dental Association)
|March 8, 2003
PubMed
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Cherubism, a rare bone disease, causes painless jaw enlargement. This case study details cherubism in two siblings, contributing to the understanding of this genetic condition.

Area of Science:

  • Genetics and Bone Diseases
  • Oral and Maxillofacial Pathology

Background:

  • Cherubism is a rare, non-neoplastic bone disorder.
  • It presents as bilateral, painless jaw enlargements, leading to a characteristic 'cherubic' facial appearance.

Observation:

  • Radiographic examination reveals bilateral multilocular radiolucent jaw lesions.
  • Histopathology shows proliferating fibrous connective tissue with numerous multinucleated giant cells.

Findings:

  • This report details two siblings affected by cherubism.
  • The condition can be sporadic or familial, often spanning multiple generations.

Implications:

  • Understanding cherubism aids in accurate diagnosis and management.
  • Further research into the genetic basis of cherubism is warranted.

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