Related Experiment Video
Updated: Sep 27, 2026

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
[Pneumonia in the patient with chronic obstructive pulmonary disease. Levels of severity and risk classification]
J M Ruiz De Oña1, M Gómez Fernández, J Celdrán
1Unidad de Gestión Clínica de Neumología. Hospital Nuestra Señora del Prado. Talavera de la Reina. Toledo. España. jmruiz@separ.es
Objectives:
To analyze the severity, clinical course and mortality in patients with community-acquired pneumonia and COPD.
Method:
Retrospective study of patients admitted with pneumonia over a period of 12 months. From records, we gathered information related to patient characteristics, signs and symptoms and concomitant disease and classified each patient according to risk.
Results:
One hundred twenty-nine patients with a mean age of 71.13 (SD 17) were identified; 43 (33.3%) had COPD with severe airflow obstruction (FEV1 937 mL, SD 309), although there were no differences from one risk classification to another. No significant differences were found in mortality, as 8 patients (18.6%) with COPD died and 9 patients (10.7%) without COPD. The length of hospital stay was similar in both groups. Patients with COPD suffered more severe pneumonia and were at higher risk (classes IV and V). The percentage of COPD patients using chronic domiciliary oxygen therapy who died (75%) was different from the percentage of such patients who lived (37%); percent mortality also differed by level of risk. Patients receiving oxygen therapy had greater obstruction and greater respiratory insufficiency upon admission (PaO2/FiO2: 216.9, SD 41.92).
Conclusions:
The mortality rates and mean hospital stays of patients with and without COPD who are admitted with community-acquired pneumonia are similar, but patients with COPD suffer more severe pneumonia. Mortality is higher in patients with community-acquired pneumonia and COPD who are receiving domiciliary oxygen therapy and have greater airflow obstruction and respiratory deterioration upon admission.
Related Concept Videos
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia I: Introduction
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Pneumonia III: Complications and Assessment
Chronic Obstructive Pulmonary Disease-I: Introduction
Pneumonia II: Pathophysiology