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[99mTc] liposomes for localizing experimental colitis in a rabbit model
Vibhudutta Awasthi1, Beth Goins, Linda McManus
1Department of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, Texas 78229-3900, USA. awasthi@uthscsa.edu
Abstract:
[(99m)Tc] liposomes (TL) and [(111)In]WBCs (WBCs) were compared for imaging colitis in rabbits. At 24 h, liver was the major organ of accumulation (7.8% TL vs 39.7% WBCs), besides blood (44.1% TL vs 24.4% WBCs) and spleen (0.3% TL vs 7% WBCs). The inflamed colon accumulated 37.1 times more of [(99m)Tc] liposomes than the normal colon whereas the ratio was only 15.2 in case of [(111)In] WBCs. The study demonstrates the usefulness of [(99m)Tc] liposomes for imaging inflammatory bowel diseases.