Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prediction of Setschenow constants.

Nina Ni1, Samuel H Yalkowsky

  • 1College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA. na@pharmacy.arizona.edu

International Journal of Pharmaceutics
|March 8, 2003
PubMed
Summary

The salting out constant, influenced by sodium chloride, is better described by a drug

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Derivation expansion of the general solubility equation (GSE).

Journal of pharmaceutical sciences·2026
Same author

Ion pairing enhances hydroquinone stability toward oxygen in aqueous electrochemical carbon dioxide capture.

Nature communications·2025
Same author

A cluster of articles in memory of Rodolfo Pinal, Ph.D.

Journal of pharmaceutical sciences·2025
Same author

Reversible CO<sub>2</sub> Capture and On-Demand Release by an Acidity-Matched Organic Photoswitch.

Journal of the American Chemical Society·2023
Same author

FDA Approval Summary: Oral Azacitidine for Continued Treatment of Adults with Acute Myeloid Leukemia Unable to Complete Intensive Curative Therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research·2022
Same author

Machine learning transition temperatures from 2D structure.

Journal of molecular graphics & modelling·2021

Area of Science:

  • Physical Chemistry
  • Pharmaceutical Science

Background:

  • The Setschenow (salting out) constant describes the effect of salts on the solubility of non-electrolytes.
  • Understanding salting out phenomena is crucial for drug formulation and delivery.
  • Previous studies have explored relationships between salting out constants and various solute properties.

Purpose of the Study:

  • To validate a proposed relationship between the salting out constant and the partition coefficient of drug solutes.
  • To compare the efficacy of partition coefficient, molar volume, and aqueous solubility as descriptors of salting out.

Main Methods:

  • The study analyzed the Setschenow constant for drug solutes in the presence of sodium chloride.
  • Correlations were examined between the Setschenow constant and solute properties: molar volume, aqueous solubility, and octanol-water partition coefficient (Kow).

Main Results:

  • A previously proposed relationship between the salting out constant and the partition coefficient was validated.
  • The partition coefficient (Kow) was found to be a superior descriptor of salting out compared to molar volume and aqueous solubility.

Conclusions:

  • The octanol-water partition coefficient is a key parameter for predicting and understanding the salting out behavior of drugs.
  • This finding can aid in optimizing drug solubility and formulation strategies through salt manipulation.

Related Experiment Videos