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Updated: Jun 30, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

Vancomycin-resistant enterococci: 15 years and counting.

L S Chavers1, S A Moser, W H Benjamin

  • 1Department of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham, Alabama 35249, USA.

The Journal of Hospital Infection
|March 8, 2003
PubMed
Summary
This summary is machine-generated.

This study reviews vancomycin-resistant enterococci (VRE) history and proposes a model for VRE disease progression in hospitals. Understanding VRE reservoirs, patient factors, and antimicrobial use can guide interventions.

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Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Published on: December 23, 2022

Area of Science:

  • Infectious Diseases
  • Hospital Epidemiology
  • Antimicrobial Resistance

Background:

  • Vancomycin-resistant enterococci (VRE) pose a significant threat in healthcare settings.
  • Understanding the factors contributing to VRE colonization and infection is crucial for effective control.

Purpose of the Study:

  • To review the history of VRE.
  • To propose a causal model for VRE disease progression in hospitalized patients.
  • To discuss differences between VRE colonization and infection and their implications for surveillance and intervention.

Main Methods:

  • Review of VRE history and epidemiology.
  • Development of a causal model for VRE disease progression.
  • Documentation of clonal VRE transmission in a teaching hospital.

Main Results:

  • A causal model was proposed, highlighting exposure to VRE reservoirs, patient characteristics, antimicrobial exposure, and VRE prevalence as key factors.
  • Differences in VRE colonization versus infection were analyzed concerning surveillance methods.
  • Clonal transmission of VRE was observed, with demonstrated susceptibility to various antimicrobial agents.

Conclusions:

  • The proposed model can identify modifiable factors for targeted VRE interventions.
  • Effective hospital surveillance and antimicrobial stewardship are essential for VRE control.