Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antibiotic Selection00:57

Antibiotic Selection

Overview
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
Stringent Response in E. coli01:23

Stringent Response in E. coli

Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of a chimeric ELISA to investigate immunoglobulin E antibody responses to Der p 1 and Der p 2 in mite-allergic patients with asthma, wheezing and/or rhinitis.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2002
Same author

Motor vehicle occupant crashes among teens: impact of the graduated licensing law in San Diego.

Annual proceedings. Association for the Advancement of Automotive Medicine·2002
Same author

Factors affecting men's liking of condoms they have used.

International journal of STD & AIDS·2002
Same author

Characterisation of two serine protease inhibitors expressed in the pituitary gland.

Archives of physiology and biochemistry·2002
Same author

Structures of prevention: a safe-sex/safe-injecting audit of Mount Alexander Shire, a methodological pilot.

The Australian journal of rural health·2002
Same author

Euthanasia: the strength of the middle ground.

Medical law review·2002
Same journal

Expression of concern: Postoperative serum amyloid A as a primary marker in a predictive model for ventilator-associated pneumonia in elderly patients with acute ischaemic stroke undergoing endovascular therapy with general anaesthesia [Journal of Hospital Infection, pre-proof, available online 8 July 2025].

The Journal of hospital infection·2026
Same journal

Past lessons for the 2026 Bundibugyo virus outbreak: filovirus infection prevention in conflict-affected settings.

The Journal of hospital infection·2026
Same journal

Global randomised controlled trials in infection prevention and control: a bibliographic review from the past two decades.

The Journal of hospital infection·2026
Same journal

Transmission of Dry Surface Biofilm Via and Through Cotton Bedsheets: Implications for Hospital Infection Control.

The Journal of hospital infection·2026
Same journal

Eliminating S. aureus colonization prior to surgery through screening and decolonisation measures in the outpatient setting: How well does outpatient decolonisation work in practice from the patients' perspective?

The Journal of hospital infection·2026
Same journal

Erratum to "Improving hygiene compliance among family caregivers through infection prevention and control interventions in Bangladeshi hospitals: a pilot study" [J Hosp Infect 171 (2026) 174-182].

The Journal of hospital infection·2026
See all related articles

Related Experiment Video

Updated: Jun 30, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

Vancomycin-resistant enterococci: 15 years and counting.

L S Chavers1, S A Moser, W H Benjamin

  • 1Department of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham, Alabama 35249, USA.

The Journal of Hospital Infection
|March 8, 2003
PubMed
Summary
This summary is machine-generated.

This study reviews vancomycin-resistant enterococci (VRE) history and proposes a model for VRE disease progression in hospitals. Understanding VRE reservoirs, patient factors, and antimicrobial use can guide interventions.

More Related Videos

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing
09:44

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Published on: December 23, 2022

Related Experiment Videos

Last Updated: Jun 30, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing
09:44

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Published on: December 23, 2022

Area of Science:

  • Infectious Diseases
  • Hospital Epidemiology
  • Antimicrobial Resistance

Background:

  • Vancomycin-resistant enterococci (VRE) pose a significant threat in healthcare settings.
  • Understanding the factors contributing to VRE colonization and infection is crucial for effective control.

Purpose of the Study:

  • To review the history of VRE.
  • To propose a causal model for VRE disease progression in hospitalized patients.
  • To discuss differences between VRE colonization and infection and their implications for surveillance and intervention.

Main Methods:

  • Review of VRE history and epidemiology.
  • Development of a causal model for VRE disease progression.
  • Documentation of clonal VRE transmission in a teaching hospital.

Main Results:

  • A causal model was proposed, highlighting exposure to VRE reservoirs, patient characteristics, antimicrobial exposure, and VRE prevalence as key factors.
  • Differences in VRE colonization versus infection were analyzed concerning surveillance methods.
  • Clonal transmission of VRE was observed, with demonstrated susceptibility to various antimicrobial agents.

Conclusions:

  • The proposed model can identify modifiable factors for targeted VRE interventions.
  • Effective hospital surveillance and antimicrobial stewardship are essential for VRE control.