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Correlation between candiduria and departmental antibiotic use.
M Weinberger1, S Sweet, L Leibovici
1The Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel. miriw@netvision.net.il
The Journal of Hospital Infection
|March 8, 2003
Summary
Rising candiduria in hospitals is linked to antibiotic use. This study found a strong correlation between departmental antibiotic consumption, especially broad-spectrum agents like meropenem, and increased candiduria rates in patients.
Area of Science:
- Infectious Diseases
- Hospital Epidemiology
- Antimicrobial Stewardship
Background:
- Increasing incidence of candiduria (yeast in urine) in teaching hospitals.
- Need to understand factors contributing to this rise, particularly antibiotic consumption patterns.
Purpose of the Study:
- To investigate the correlation between departmental antibiotic consumption and the incidence of candiduria in a large teaching hospital.
- To identify specific antibiotic classes or agents most strongly associated with candiduria.
Main Methods:
- Retrospective analysis of data from a large teaching hospital in Israel.
- Correlation analysis between departmental intravenous antibiotic consumption (DDD/1000 patient-days) and candiduria incidence (per 1000 patient-days).
Main Results:
- A significant positive correlation was found between overall antibiotic consumption and candiduria incidence (r=0.47, P=0.03).
- Broad-spectrum antibiotic use showed a stronger correlation (r=0.66, P=0.001).
- Meropenem (r=0.79, P<0.001) and ceftazidime (r=0.66, P=0.001) exhibited the strongest associations with candiduria.
Conclusions:
- Departmental antibiotic prescribing habits are strongly correlated with the incidence of candiduria in hospitalized patients.
- Findings support strategies for restricting the use of broad-spectrum antibiotics to control candiduria.
- Highlights the importance of antimicrobial stewardship in managing hospital-acquired infections.