Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Isoprenoid pathway dysfunction in human male infertility.

R K Kurup1, P A Kurup

  • 1Department of Medicine, Medical College Hospital, Trivandrum, Kerala, India.

Archives of Andrology
|March 8, 2003
PubMed
Summary

The isoprenoid pathway is altered in male infertility, showing increased digoxin and dolichol, and decreased ubiquinone. These changes impact membrane function and oxidative stress, contributing to oligospermia and reduced motility.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Digoxin : a model for hypothalamic regulation of neuronal transmission, endocrine function, immunity and cytodifferentiation.

Neurology India·2018
Same author

Changes in the glycosaminoglycans, glycoproteins and lipid components of erythrocyte membrane in neuroacanthocytosis.

Neurology India·2018
Same author

Hypothalamic digoxin and brain function.

Acta neuropsychiatrica·2016
Same author

The antibacterial principle of Withania somnifera. I. Isoation and antibacterial activity.

Antibiotics & chemotherapy (Northfield, Ill.)·2014
Same author

Hypothalamic digoxin and schizophrenia - a model for conscious and subliminal perception and its dysfunction in schizophrenia.

Indian journal of psychiatry·2011
Same author

Endogenous sodium potassium ATPase inhibition related biochemical cascade and the acquired immunodeficiency syndrome--neural regulation of viral replication and immune response to the virus.

Indian journal of dermatology, venereology and leprology·2007

Area of Science:

  • Biochemistry
  • Metabolomics
  • Reproductive Biology

Background:

  • The isoprenoid pathway yields critical metabolites: digoxin (Na(+)-K(+) ATPase regulation), dolichol (protein N-glycosylation), and ubiquinone (antioxidant).
  • Dysregulation of this pathway may contribute to various pathologies, including male infertility.

Purpose of the Study:

  • To investigate the isoprenoid pathway's role in human male infertility (oligospermia, reduced motility).
  • To compare isoprenoid pathway metabolites in infertile men with hemispheric dominance patterns.

Main Methods:

  • Assessed isoprenoid pathway metabolites in male infertility patients and controls.
  • Measured membrane Na(+)-K(+) ATPase activity, serum magnesium, tryptophan/tyrosine catabolites, dolichol, glycoconjugates, and ubiquinone.
  • Analyzed lysosomal stability and serum lysosomal enzymes.

Main Results:

  • Upregulated isoprenoid pathway with increased digoxin synthesis observed in all patient groups.
  • Reduced membrane Na(+)-K(+) ATPase activity, serum magnesium, and tyrosine catabolites.
  • Increased tryptophan catabolites, dolichol, glycoconjugates, free radicals, and cholesterol:phospholipid ratio.
  • Decreased ubiquinone levels and lysosomal stability.

Conclusions:

  • Altered isoprenoid pathway metabolism is implicated in human male infertility.
  • Observed metabolic changes, including oxidative stress and altered membrane composition, may contribute to pathogenesis.
  • Correlation with right hemispheric dominance suggests potential neuro-metabolic links.

Related Experiment Videos