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Updated: Sep 7, 2026
Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
Published on: March 11, 2016
Serum lipids and age-related lens opacities: a longitudinal investigation: the Framingham Studies
Rita Hiller1, Robert D Sperduto, George F Reed
1Division of Epidemiology and Clinical Research, National Eye Institute, Building 31 Room 6A52, 31 Center Drive, Bethesda, MD 20892-2510, USA.
Objective:
To investigate whether serum lipid/lipoprotein levels are independent risk factors for nuclear, cortical, or posterior subcapsular (PSC) cataracts.
Design:
Case-control study nested in a cohort study.
Participants And Methods:
Eye examinations were conducted on surviving members of the Framingham Offspring Heart Study cohort from 1989 to 1991 (Framingham Offspring Eye Study) to determine cataract case-control status. Data from the Framingham Offspring Heart Study, including fasting serum total cholesterol, high-density lipoprotein cholesterol, and triglyceride measurements collected first in 1971, again approximately 8 years later, and approximately every 4 years thereafter were used to examine associations between lipid levels (mean levels across examinations and slope of measurements over time) and the presence of specific cataract types. The multistage analyses included 1869 persons aged 45 years and older.
Main Outcome Measures:
A standardized grading system was used to grade cortical, nuclear, and PSC cataracts.
Results:
The median age of participants was 55 years; 49% were males. In multivariable logistic regression models adjusted for potential confounders, fasting hypertriglyceridemia (>/=250 mg/dl) was associated with an increased risk of PSC cataract in men (P = 0.02). High-density lipoprotein cholesterol levels
Conclusions:
These findings suggest that hypertriglyceridemia, a potentially modifiable factor, is associated with the development of PSC cataract in men.
