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Updated: Aug 9, 2026

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery
Published on: July 31, 2014
[Intracerebral hematoma associated with reduced apparent diffusion coefficient mimicking acute stroke]
B Randoux1, B Marro, D Dormont
1Service de Neuroradiologie, Groupe hospitalier Pitié-Salpêtrière, Paris. bruno.randoux@caramail.com
Abstract:
We report the case of a 67 year old patient admitted at our institution for acute onset of left hemiplegia. MRI was done 2 h 30 after symptom onset. Diffusion weighted images showed a hyperintense lesion in the right basal ganglia region with restricted apparent diffusion coefficient (ADC=428. 10(-6) mm(2)/s), a 50% decrease in value compared to the normal left side, consistent with acute ischemia. The lesion was hyperintense and moderately heterogeneous at FLAIR imaging, best seen on echo planar T2W images, with hypointense rim consistent with magnetic susceptibility artifact. The appearance and location of the lesion suggested the possibility of hematoma, which was confirmed at CT. Interpretation of ADC values must be performed in correlation with results at imaging including sequences sensitive to magnetic susceptibility artifacts such as echo planar T2*W and T2W sequences in order to exclude the possibility of underlying hematoma.
Insights
Acute stroke imaging can be challenging. Restricted diffusion on MRI may indicate ischemia, but careful interpretation with susceptibility-sensitive sequences is crucial to rule out underlying hematoma.
Area of Science:
- Neurology
- Radiology
- Neuroimaging
Background:
- Acute ischemic stroke diagnosis relies heavily on neuroimaging.
- Diffusion-weighted imaging (DWI) is sensitive to early ischemic changes.
Observation:
- A 67-year-old patient presented with acute hemiplegia.
- MRI revealed a basal ganglia lesion with restricted apparent diffusion coefficient (ADC), suggestive of acute ischemia.
- However, susceptibility artifacts on echo planar T2W images raised suspicion for hematoma, later confirmed by CT.
Findings:
- Restricted ADC values in acute stroke can be mimicked by hematoma.
- Magnetic susceptibility artifacts on specific MRI sequences (T2*W, T2W) are key indicators for differentiating ischemia from hemorrhage.
- Correlation of DWI findings with CT is essential for accurate diagnosis.
Implications:
- Accurate differentiation between ischemic stroke and intracranial hemorrhage is critical for timely and appropriate treatment.
- Clinicians should consider hematoma in the differential diagnosis of basal ganglia lesions with restricted diffusion, especially when susceptibility artifacts are present.
- Integrating multiple imaging sequences and modalities improves diagnostic accuracy in acute neurological events.
Related Concept Videos
Ischemic Stroke ll: Pathophysiology
Hemorrhagic Stroke l: Introduction
Hemorrhagic Stroke ll: Pathophysiology
Transient Ischemic Attack l: Introduction
Cerebral Edema ll: Pathophysiology

