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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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No association between thrombosis and factor V gene polymorphisms in Chinese Han population

Hu Yanqing1, Chen Fangping, Xie Qinzhi

  • 1Department of Hematology, Xiangya Hospital of Central South University, Changsha 410008, China.

Thrombosis and Haemostasis
|March 8, 2003
PubMed

Activated protein C resistance (APCR) is the most common hereditary condition of thrombosis in Western countries. And it is significantly linked to a single nucleotide polymorphisms (SNPs) in the coagulation factor V gene that results in the mutations at R506, R306 and HR2 alleles. To determine the prevalence of APCR and its association with the factor V gene SNPs in Chinese Han thrombotic patients, we investigated a total of 346 Chinese thrombotic patients and 140 normal controls for APCR using the APTT-based assays, according to manufacturer's instructions, APC ratio

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