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Related Experiment Videos

[Transgenic mice as disease models].

Mikkel Bruhn Schuster1, Bo Torben Porse

  • 1Laboratorium for Genterapiforskning, H:S Rigshospitalet, DK-2100 København ø.

Ugeskrift for Laeger
|March 11, 2003
PubMed
Summary

Transgenic animal models are powerful tools for studying diseases. Advances in genomic manipulation allow precise tailoring of mouse genomes to investigate human disease causes.

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Area of Science:

  • Genetics and Genomics
  • Animal Models
  • Disease Etiology

Context:

  • Transgenic animal models are crucial for biological research.
  • Genomic manipulation technologies have advanced significantly.
  • Availability of human and murine genomic sequences enables precise genome editing.

Purpose:

  • To review systems employing transgenic animal models for studying human disease.
  • To highlight the role of precise genome tailoring in disease research.

Summary:

  • This review discusses the application of transgenic animal models in understanding disease.
  • It details how genomic manipulation and sequencing facilitate the creation of tailored mouse models.
  • Examples of systems used to study human disease etiology are presented.

Impact:

  • Enhanced understanding of basic biology and disease mechanisms.
  • Facilitates the development of new research models for human diseases.
  • Supports the investigation into the causes and progression of various human pathologies.

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