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Novel "three-in-one" peptide device for genetic drug delivery
Jason Smith1, Jesse Guidry, Pernilla Wittung-Stafshede
1Molecular and Cellular Biology Graduate Program, and Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, USA.
Protein and Peptide Letters
|March 11, 2003
Abstract:
We here describe a new strategy for the delivery of oligonucleotides to cells that is based on the use of a short peptide containing three functional units: a membrane-penetrating segment, a DNA-binding domain and a cell-localization sequence. The designed vector binds strongly to oligonucleotides and has membrane-perturbing abilities in vitro. This type of multi-functional device may be a powerful tool to achieve efficient delivery of genetic drugs in vivo.