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A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
Competent cellular immunity in allergic rhinitis patients with elevated IgE.
The Journal of Allergy and Clinical Immunology
|April 1, 1976
Summary
Allergic rhinitis patients with high IgE levels show normal cell-mediated immunity (CMI). Elevated immunoglobulin E (IgE) did not impair CMI parameters in this study.
Area of Science:
- Immunology
- Allergy Research
Background:
- Allergic rhinitis is often associated with elevated total serum IgE.
- The impact of high IgE on cell-mediated immunity (CMI) requires further investigation.
Purpose of the Study:
- To investigate cell-mediated immunity (CMI) parameters in allergic rhinitis patients with markedly elevated total serum IgE.
- To determine if high IgE levels correlate with impaired CMI.
Main Methods:
- Compared CMI parameters between 17 allergic rhinitis patients (IgE > 300 IU/ml) and 14 healthy controls.
- Assessed delayed cutaneous hypersensitivity, lymphocyte transformation (mitogen and antigen-stimulated), and sheep erythrocyte rosettes.
Main Results:
- Allergic patients had significantly higher mean serum IgE (1,421 IU/ml) than controls (101 IU/ml).
- No significant differences in delayed hypersensitivity, lymphocyte transformation, or T-cell rosettes were observed.
- Allergic patients showed a higher percentage of sheep erythrocyte-antibody-complement rosettes.
Conclusions:
- Markedly elevated total serum IgE in allergic rhinitis is not associated with detectable impairment of cell-mediated immunity.
- CMI appears to be preserved despite significantly high IgE levels in these patients.
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