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Related Experiment Videos

A statistically valid alternative to the TDT.

K M Wittkowski1, X Liu

  • 1General Clinical Research Center, The Rockefeller University, New York, NY 10021, USA. kmw@rockefeller.edu

Human Heredity
|March 11, 2003
PubMed
Summary
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A new statistical test, the stratified McNemar test (SMN), offers a more powerful and conservative alternative to the transmission/disequilibrium test (TDT) for genetic linkage analysis. This formally derived test improves upon the TDT by providing a simpler, more reliable method for genetic studies.

Area of Science:

  • Statistical genetics
  • Genetic epidemiology
  • Human genetics

Background:

  • The transmission/disequilibrium test (TDT) is a common method for detecting genetic linkage.
  • The TDT's statistical properties, particularly its conservativeness and power, have not been fully explored.

Purpose of the Study:

  • To introduce an alternative linkage test to the TDT.
  • To develop a test that is conservative under the null hypothesis and more powerful under alternatives.

Main Methods:

  • Examined the exact distribution of the TDT under null and alternative hypotheses.
  • Rewrote the TDT based on parental mating types.
  • Replaced the multinomial variance estimate with a binomial variance.

Main Results:

Related Experiment Videos

  • The proposed test is identified as the stratified McNemar test (SMN).
  • The SMN maintains a conservative significance level compared to the chi-squared distribution, unlike the TDT.
  • The SMN demonstrates greater statistical power than the TDT under alternative hypotheses.

Conclusions:

  • The SMN is a formally derived and computationally simple alternative to the TDT.
  • The SMN offers improved statistical properties, including conservativeness and power, for genetic linkage analysis.