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Construct validity of the abbreviated mental test in older medical inpatients
R Antonelli Incalzi1, M Cesari, C Pedone
1Centro di Medicina dell'Invecchiamento, Università Cattolica del Sacro Cuore, Roma, Italia.
Objectives:
To evaluate validity and internal structure of the Abbreviated Mental Test (AMT), and to assess the dependence of the internal structure upon the characteristics of the patients examined.
Design:
Cross-sectional examination using data from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA) database.
Setting:
Twenty-four acute care wards of Geriatrics or General Medicine.
Participants:
Two thousand eight hundred and eight patients consecutively admitted over a 4-month period.
Measurements:
Demographic characteristics, functional status, medical conditions and performance on AMT were collected at discharge. Sensitivity, specificity and predictive values of the AMT <7 versus a diagnosis of dementia made according to DSM-III-R criteria were computed. The internal structure of AMT was assessed by principal component analysis. The analysis was performed on the whole population and stratified for age (<65, 65-80 and >80 years), gender, education (<6 or >5 years) and presence of congestive heart failure (CHF).
Results:
AMT achieved high sensitivity (81%), specificity (84%) and negative predictive value (99%), but a low positive predictive value of 25%. The principal component analysis isolated two components: the former component represents the orientation to time and space and explains 45% of AMT variance; the latter is linked to memory and attention and explains 13% of variance. Comparable results were obtained after stratification by age, gender or education. In patients with CHF, only 48.3% of the cumulative variance was explained; the factor accounting for most (34.6%) of the variance explained was mainly related to the three items assessing memory.
Conclusion:
AMT >6 rules out dementia very reliably, whereas AMT <7 requires a second level cognitive assessment to confirm dementia. AMT is bidimensional and maintains the same internal structure across classes defined by selected social and demographic characteristics, but not in CHF patients. It is likely that its internal structure depends on the type of patients. The use of a sum-score could conceal some part of the information provided by the AMT.