Related Experiment Video
Updated: Sep 2, 2026

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice
Published on: February 11, 2019
Budesonide: a novel treatment for oral chronic graft versus host disease
Sharon Elad1, Reuven Or, Adi A Garfunkel
1Hospital Oral Medicine Department, Hadassah University Hospital and The Hebrew University-Hadassah School Of Dental Medicine, Jerusalem, Israel. eladhome@md.huji.ac.il
Objective:
This clinical trial aims to evaluate the efficacy of budesonide, a newly registered steroid with high potency and low bioavailability, for the treatment of chronic oral graft versus host disease (GVHD).
Study Design:
Twelve patients with chronic resistant oral GVHD were treated with 3 mg budesonide/5 ml saline 2 to 3 times a day for up to 3 months. Oral manifestations were monitored, and mucosal response scored.
Results:
All patients responded positively to the mouthwash, and 7 of the 12 patients were scored as having "good" or "complete" recovery by both examiner and subject. An early response noted within the first 2 to 3 weeks of treatment was complemented by a probable cumulative effect seen during the first months of treatment.
Conclusion:
Budesonide is suggested as an alternative treatment for chronic oral GVHD.
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08:05Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
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