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Updated: Aug 13, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
Population pharmacokinetics/pharmacodynamics relationships of an anticancer drug
1UMR 181, Physiopathologie et Toxicologie Expérimentales, Ecole Vétérinaire de Toulouse, 23 chemin des Capelles, 31076 Toulouse Cedex, France.
Abstract:
This paper proposes a method for studying the toxicity of an anticancer drug with a delayed effect. The goal is to predict a dosage regimen with controlled toxicity. To this end, a semi-physiological model is used. A limit of toxicity is demonstrated, which is intrinsic to the model. It reduces the effect of high drug concentrations. This limit explains the mixed behaviour of the drug: time-dependence and concentration-dependence, according to the dose actually administered. A population analysis is performed to estimate the parameters of the model, and to predict a safe dosage regimen.
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