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B-cell leukemia in a sheep.

B A Valentine1, S P McDonough

  • 1Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis 97331, USA. beth.valentine@orst.edu

Veterinary Pathology
|March 12, 2003
PubMed
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This study details a case of B-cell leukemia in an 8.5-year-old Finnish ewe, identified through necropsy and histopathology. The findings highlight atypical mononuclear cell infiltration across multiple organs, characteristic of this hematologic malignancy.

Area of Science:

  • Veterinary Pathology
  • Hematology
  • Oncology

Background:

  • Necropsy was performed on an 8.5-year-old Finnish ewe presenting with respiratory distress, cachexia, and weakness.
  • The clinical signs prompted euthanasia and subsequent postmortem examination to determine the underlying cause.

Observation:

  • Gross findings included a diffusely enlarged, friable liver, mild splenomegaly, and mesenteric lymphadenopathy.
  • Histopathological examination revealed intravascular atypical mononuclear cells in all examined tissues.
  • A leukemic pattern of infiltration was observed in the mesenteric lymph nodes, liver, lung, and spleen.

Findings:

  • Immunohistochemical analysis showed neoplastic cells were positive for CD79a.
  • The neoplastic cells were negative for CD-3, BLA.36, and CD68 leukocytic markers.

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  • The diagnostic criteria supported a final diagnosis of B-cell leukemia.

    • Implications:

    • This case contributes to the understanding of B-cell leukemia in sheep.
    • The findings underscore the importance of comprehensive histopathological and immunohistochemical evaluation in diagnosing hematologic malignancies in animals.
    • Further research may elucidate the specific etiology and progression of B-cell leukemia in this species.