Allergic reaction to platinum in silicone breast implants
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Updated: Sep 27, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Sambasiva R Arepalli1, Shewit Bezabeh, S Lori Brown
1Division of General, Restorative, and Neurological Devices, Office of Device Evaluation, Food and Drug Administration, Rockville, Maryland 20850, USA.
Abstract:
Platinum is used as a catalyst in the manufacture of silicone breast implants. Because platinum is recognized as a potent sensitizer in certain circumstances, some have expressed concern that women with silicone breast implants are exposed to platinum, which is causing allergic reactions. We searched the literature for information on the level of platinum in breast implants and reports of sensitization that clearly related to platinum in women with breast implants. We found no published report with convincing evidence that platinum causes allergic reactions in women with breast implants or that women with breast implants are any more likely to have allergic reactions than women without breast implants.
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