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Cardiovascular risk factors associated with pulse pressure in a screened cohort in Okinawa, Japan

Taku Inoue1, Mitsuteru Matsuoka, Kazufumi Nagahama

  • 1Third Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan. imtak-ryk@umin.ac.jp

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|March 12, 2003
PubMed

Insights

Higher pulse pressure (PP) is linked to increased cardiovascular risk factors in adults. This association between elevated PP and conditions like diabetes and obesity was observed in both men and women.

Area of Science:

  • Cardiology
  • Public Health

Background:

  • Pulse pressure (PP) is a potential indicator of cardiovascular health.
  • Understanding the relationship between PP and cardiovascular risk factors is crucial for preventative strategies.

Purpose of the Study:

  • To evaluate the association between pulse pressure (PP) and various cardiovascular risk factors in a large screened cohort.
  • To determine if these associations differ between men and women.

Main Methods:

  • A cohort of 8,508 subjects (5,299 men, 3,209 women) aged 18-89 years was analyzed.
  • Exclusion criteria included medication use for hypertension/heart disease, no ECG, or arrhythmia history.
  • Subjects were categorized into four PP groups, and multiple regression analysis was employed.

Main Results:

  • In men, PP was associated with age, diabetes mellitus, uric acid, body mass index, heart rate, smoking, and drinking.
  • In women, PP was associated with age, diabetes mellitus, body mass index, heart rate, and exercise.
  • A significant increase in PP was observed with a higher number of risk factors, including diabetes mellitus, obesity, drinking, elevated heart rate, and hyperuricemia, in both sexes.

Conclusions:

  • Higher pulse pressure is significantly associated with multiple cardiovascular risk factors.
  • These associations were consistent in both men and women, highlighting PP as a relevant clinical marker.

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