[Gynecomastia secondary to Leydig cell tumor]

Area of Science:

• Pediatric Endocrinology
• Oncology
• Reproductive Medicine

Background:

• Leydig cell tumors are rare testicular neoplasms.
• Hormonal imbalances, including elevated estradiol and decreased testosterone, can cause gynecomastia in adolescents.

Observation:

• A 16-year-old male presented with bilateral gynecomastia, elevated estradiol, and decreased testosterone.
• Testicular ultrasonography identified a left testicular tumor, leading to orchidectomy.

Findings:

• Histopathological analysis confirmed a Leydig cell tumor.
• Post-surgery, gynecomastia resolved, and hormone levels normalized within two months.
• A two-year follow-up showed no tumor recurrence.

Implications:

• This case highlights the importance of considering Leydig cell tumors in adolescent males with unexplained gynecomastia.
• Surgical intervention is an effective treatment for Leydig cell tumors, leading to hormonal normalization and symptom resolution.
• Early diagnosis and treatment are crucial for favorable outcomes and preventing long-term complications.