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Massive perivillous fibrinoid causing recurrent placental failure
1Department of Histopathology, Rotunda Hospital, Dublin, Ireland.
Summary
Massive perivillous fibrinoid (MPF) affects 0.028% of pregnancies, leading to intrauterine growth restriction and preterm delivery. This condition has an 18% recurrence rate, indicating chronic placental insufficiency.
Area of Science:
- Obstetrics and Gynecology
- Perinatal Medicine
- Pathology
Background:
- Massive perivillous fibrinoid (MPF) is a placental pathology.
- Its incidence, recurrence, and adverse outcomes require further investigation.
Purpose of the Study:
- To determine the incidence and recurrence rate of MPF.
- To evaluate the perinatal outcomes associated with MPF.
Main Methods:
- Retrospective analysis of placental histology (1991-1998).
- Review of maternal case records.
- Study conducted at the Rotunda Hospital, Dublin.
Main Results:
- MPF incidence was 0.028%.
- Recurrence rate was approximately 18%.
- Associated with intrauterine growth restriction (100%), fetal loss (31%), and preterm delivery (33%).
Conclusions:
- MPF is linked to intrauterine death, growth restriction, and preterm birth.
- Significant recurrence rate suggests a chronic placental insufficiency syndrome.