Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmaco-toxicological study of diterpenoids.

Carla Delporte1, Nadine Backhouse, Pedro Salinas

  • 1Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, 233, 1-Santiago, Casilla, Chile. cdelpor@uchile.cl

Bioorganic & Medicinal Chemistry
|March 12, 2003
PubMed
Summary

Andean plants Azorella compacta, Azorella yareta, and Laretia acaulis show anti-inflammatory and analgesic effects. Their diterpenoid compounds, azorellanol and 13-hydroxy-7-oxoazorellane, validated traditional medicine uses without toxicity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Next generation sequencing of circulating tumor DNA for precision medicine in patients with advanced biliary tract cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Erratum to'Neuroprotective and gut health benefits of Ugni molinae in preclinical Huntington's disease models' [Experimental Neurology, Volume 393 (2025) 115406].

Experimental neurology·2025
Same author

Neuroprotective and gut health benefits of Ugni molinae in preclinical Huntington's disease models.

Experimental neurology·2025
Same author

Epibiotic bacterial community composition varies during different developmental stages of Octopus mimus: Study of cultivable representatives and their secondary metabolite production.

PloS one·2025
Same author

Comprehensive Assessment of Anti-Inflammatory, Antiproliferative and Neuroprotective Properties of Cauliflower after Dehydration by Different Drying Methods.

Foods (Basel, Switzerland)·2024
Same author

<i>Azorella compacta</i> Organic Extracts Exacerbate Metabolic Dysfunction-Associated Fatty Liver Disease in Mice Fed a High-Fat Diet.

Pharmaceuticals (Basel, Switzerland)·2024

Area of Science:

  • Ethnobotany
  • Pharmacology
  • Natural Product Chemistry

Background:

  • Traditional use of Andean Apiaceae species (Azorella compacta, Azorella yareta, Laretia acaulis) for respiratory ailments with inflammation and pain.
  • Lack of scientific validation for the therapeutic benefits and toxicity of these medicinal plants.
  • Identification of three diterpenoids: azorellanol, 13-hydroxy-7-oxoazorellane, and 7-deacetylazorellanol, previously isolated from these species.

Purpose of the Study:

  • To validate the traditional medicinal uses of Azorella compacta, Azorella yareta, and Laretia acaulis.
  • To discover novel anti-inflammatory and analgesic molecules from these plant species.
  • To evaluate the farmaco-toxicological profile of isolated diterpenoids.

Main Methods:

  • Farmaco-toxicological evaluation of azorellanol, 13-hydroxy-7-oxoazorellane, and 7-deacetylazorellanol in mice.

Related Experiment Videos

  • Assessment of topical anti-inflammatory activity using arachidonic acid (AA) and 12-deoxyphorbol 13-tetradecanoate (TPA) induced edema models.
  • Evaluation of analgesic activity and acute toxicity.

    • Main Results:

    • No toxic or side effects were observed in mice for any of the tested compounds.
    • All three diterpenoids demonstrated dose-dependent inhibition of pain.
    • Azorellanol showed significant topical anti-inflammatory effects comparable to reference drugs, potentially via cyclooxygenase inhibition. 13-hydroxy-7-oxoazorellane was the most potent analgesic.
    • 13-hydroxy-7-oxoazorellane exhibited the strongest analgesic effect, though less potent than sodium naproxen.

    Conclusions:

    • The study scientifically validates the traditional anti-inflammatory and analgesic uses of Azorella compacta, Azorella yareta, and Laretia acaulis.
    • Azorellanol and 13-hydroxy-7-oxoazorellane are promising candidates for further development as anti-inflammatory and analgesic agents.
    • The findings support the ethnobotanical use of these Andean plants in folk medicine for treating inflammatory conditions.