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Synthesis and in vitro leishmanicidal activity of some hydrazides and their analogues
Khalid Mohammad Khan1, Maimona Rasheed, Zia-Ullah
1International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, -75270, Karachi, Pakistan. hassaan2@super.net.pk
Bioorganic & Medicinal Chemistry
|March 12, 2003
Abstract:
Twenty-one hydrazides were synthesized by treating different esters with hydrazine hydrate. Substituted hydrazides were obtained by treating hydrazides with alkyl/aryl/acyl halides. Some of these compounds exhibit potential in vitro leishmanicidal activity. The structures of all the synthesized compounds were confirmed by spectroscopic analysis.