Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spirometry testing standards in spinal cord injury.

Alyson Kelley1, Eric Garshick, Erica R Gross

  • 1Pulmonary and Critical Care Medicine Section, Medical Service, and Rehabilitation Medicine Service, VA Boston Healthcare System, West Roxbury, MA 02132, USA.

Chest
|March 12, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deployment-Related Respiratory Health: Bridging the Gap between Clinical and Epidemiological Associations and Disease Mechanisms An Official American Thoracic Society Workshop Report.

Annals of the American Thoracic Society·2026
Same author

Occupational Exposure to Dust and Fumes Increases Risk for Future Adverse Clinical Outcomes.

American journal of respiratory and critical care medicine·2026
Same author

Association of SARS-CoV-2 infection with incident diabetes among U.S. Veterans in a prospective longitudinal cohort.

PloS one·2026
Same author

Respiratory Oscillometry in COPD Patients with Airway Mucus Plugs: Insights from the ECLIPSE Study.

American journal of respiratory and critical care medicine·2026
Same author

Civilian Occupational Exposure to Vapors, Gas, Dust, or Fumes and Respiratory Health Among United States Military Veterans.

American journal of industrial medicine·2026
Same author

Author Correction: National analysis of cancer mortality and proximity to nuclear power plants in the United States.

Nature communications·2026
Same journal

The effect of a two-day stay at high altitude (2500 m) on right ventricular afterload and oxygen delivery in patients with pulmonary vascular disease A randomized controlled crossover trial.

Chest·2026
Same journal

A Comparative Study of Radiation Exposure in Conventional and Robotic Bronchoscopy.

Chest·2026
Same journal

Independent Prognostic Contributions of Anti-Ro52 and Anti-MDA5 in Autoimmune-Associated Interstitial Lung Disease.

Chest·2026
Same journal

Lung aeration and gas exchange in SGA or AGA infants with moderate-severe BPD: secondary analysis of the PATH-BPD study.

Chest·2026
Same journal

Lung Cancer Incidence and Mortality after Negative Low-Dose CT Screening Results.

Chest·2026
Same journal

Symptom prevalence and impact on lung cancer risk in the SUMMIT study.

Chest·2026
See all related articles

Spirometry testing in spinal cord injury (SCI) patients can be challenging due to muscle paralysis. Modified American Thoracic Society (ATS) standards, including efforts with excessive back-extrapolated volume (EBEV) and shorter expirations, improve reproducibility and reduce bias in respiratory function studies.

Area of Science:

  • Pulmonary Medicine
  • Neurology
  • Rehabilitation Medicine

Background:

  • Muscle paralysis in spinal cord injury (SCI) raises questions about the feasibility of spirometry testing adhering to American Thoracic Society (ATS) standards.
  • Accurate pulmonary function assessment is crucial for managing respiratory complications in individuals with SCI.

Purpose of the Study:

  • To examine the determinants of spirometry test failure in subjects with SCI.
  • To evaluate the impact of modified spirometry acceptability criteria on test results and reproducibility in SCI populations.

Main Methods:

  • A cross-sectional study was conducted involving veterans with SCI and nonveterans.
  • Spirometry data was collected and analyzed to assess effort duration, excessive back-extrapolated volume (EBEV), and reproducibility.

Related Experiment Videos

  • Subjects with neurologically complete cervical injury and lower respiratory pressures were specifically analyzed.

    • Main Results:

    • 83% of subjects with SCI produced expiratory efforts meeting standard duration and EBEV criteria.
    • 94% of subjects achieved reproducible forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) according to 1994 ATS standards.
    • Modified criteria, including shorter efforts and those with EBEV, would increase the proportion of acceptable spirometry tests to 94% and reproducible efforts to 92%.

    Conclusions:

    • Individuals with SCI, even those with significant respiratory muscle impairment, can perform reproducible spirometry.
    • Excluding subjects who do not meet strict ATS standards can introduce bias in SCI respiratory function research.
    • Adapting spirometry standards to include specific effort types (EBEV, short efforts) is recommended to minimize bias and enhance the validity of pulmonary function assessments in SCI.