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Increased expression of platelet-derived growth factor receptor-beta in airway fibroblasts of severe asthmatics

Christina C Lewis1, Hong Wei Chu, Jay Y Westcott

  • 1National Jewish Medical and Research Center, Denver, CO 80206, USA.

Chest
|March 12, 2003
PubMed
Abstract

No abstract available in PubMed .

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TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...