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Multiple sclerosis amongst Chinese in Taiwan.

T P Hung, D Landsborough, M S Hsi

    Journal of the Neurological Sciences
    |April 1, 1976
    PubMed
    Summary

    Multiple sclerosis (MS) exists in Taiwan, affecting females more often with earlier onset and frequent optic nerve involvement. Atypical MS cases may be more common in Oriental populations.

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    Area of Science:

    • Neurology
    • Epidemiology
    • Immunology

    Background:

    • Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system.
    • Its prevalence and clinical characteristics can vary significantly across different ethnic and geographic populations.
    • Understanding MS in non-Western populations is crucial for a comprehensive global perspective.

    Purpose of the Study:

    • To report on the clinical characteristics and prevalence of multiple sclerosis (MS) among the Chinese population in Taiwan.
    • To investigate demographic and clinical features, including disease onset, symptom patterns, and disease severity.
    • To compare findings with Western MS populations and discuss potential atypical presentations in Oriental patients.

    Main Methods:

    • Retrospective analysis of 25 clinically diagnosed multiple sclerosis (MS) cases collected over 20 years in Taiwan.
    • Inclusion of 2 autopsy cases for pathological confirmation.
    • Clinical data review including demographics, onset, symptoms, disease course, and cerebrospinal fluid (CSF) analysis.

    Main Results:

    • Multiple sclerosis (MS) is present in Taiwan, with an estimated prevalence of 0.8/100,000 in northern Taiwan.
    • A significant female preponderance (F:M = 3.2:1) was observed, with earlier disease onset in females.
    • Optic nerve involvement was most frequent at onset and throughout the disease course. Malignant forms and painful tonic spasms were more common in females. Atypical MS presentations were noted.
    • Autopsy cases revealed severe demyelination in the optic nerve and spinal cord.

    Conclusions:

    • Multiple sclerosis (MS) occurs in the Chinese population of Taiwan, though it is relatively uncommon.
    • Clinical presentation in Taiwan shows a female predominance, earlier onset in females, and frequent optic nerve and spinal cord involvement.
    • Atypical MS presentations, potentially differing from Western cases, may be more prevalent in Oriental and tropical regions.

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