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Variation in enterovirus receptor genes.

Ase Karttunen1, Tuija Pöyry, Outi Vaarala

  • 1Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland. ase.lundstrom@helsinki.fi

Journal of Medical Virology
|March 12, 2003
PubMed
Summary

Genetic variations in enterovirus receptor genes were studied in children with type 1 diabetes. While some gene variations were found, no direct link to type 1 diabetes susceptibility was identified.

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Area of Science:

  • Virology
  • Genetics
  • Immunology

Background:

  • Increased enterovirus infections precede type 1 diabetes development.
  • Genetic variations in enterovirus receptor genes may influence susceptibility.
  • This study investigates these genetic variations in relation to type 1 diabetes.

Purpose of the Study:

  • To analyze sequence variations in genes encoding common enterovirus receptors.
  • To determine if specific genetic variations are associated with type 1 diabetes.

Main Methods:

  • DNA sequencing of enterovirus receptor genes (poliovirus receptor, ICAM-1, alpha2 integrin, CAR, DAF, beta3 integrin).
  • Analysis of leukocyte DNA from 21 diabetic children and 20 healthy adults.
  • Amplification and sequencing of virus-recognizing domains.

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Main Results:

  • A heterozygous single-nucleotide polymorphism (SNP) in the poliovirus receptor gene was found in four diabetic individuals but not controls.
  • Serological studies did not confirm altered poliovirus susceptibility due to this SNP.
  • Other SNPs were identified in ICAM-1, alpha2 integrin, and CAR genes, but no pattern specific to type 1 diabetes emerged.

Conclusions:

  • Sequence variability exists in genes for enterovirus and rhinovirus receptors.
  • No direct genetic link specific to type 1 diabetes was found in the studied receptor genes.
  • Further research is needed to understand the role of enteroviruses in type 1 diabetes.