Jove
Visualize
Contact Us

Related Experiment Videos

Bioactive lipids and their receptors.

Itzchak Angel1, Adina Bar, Rachel Haring

  • 1D-Pharm Ltd, Kiryat Weizmann Science Park, PO Box 2313, Rehovot 76123, Israel. iangel@dpharm.com

Current Opinion in Drug Discovery & Development
|March 13, 2003
PubMed
Summary

Degradation products of lipids, like lysophosphatidic acid and sphingosine 1-phosphate, are active signaling molecules. They function through G protein-coupled receptors, highlighting recent advances in bioactive lipid research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Telomir-Zn restores glucose homeostasis and reduces insulin resistance in a diet-induced zebrafish model of type 2 diabetes.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

SKNY-1, a THCV Analog, Produces Weight Loss, Lipid Normalization and Attenuation of Reward-Associated Behaviors in an mc4r(G894C) Zebrafish Model of Obesity.

International journal of molecular sciences·2026
Same author

Oral administration of Ketamir-2, a novel ketamine analog, attenuates neuropathic pain in rodent models via selective NMDA antagonism.

Frontiers in pharmacology·2025
Same author

KETAMIR-2, a new molecular entity and novel ketamine analog.

Frontiers in pharmacology·2025
Same author

TVP1022: A Novel Cardioprotective Drug Attenuates Left Ventricular Remodeling After Ischemia/Reperfusion in Pigs.

Journal of cardiovascular pharmacology·2015
Same author

Combating diabetes complications by 1-Fe, a corrole-based catalytic antioxidant.

Journal of diabetes and its complications·2013
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Lipidomics
  • Cell Signaling
  • Biochemistry

Background:

  • Degradative products of glycerol- and sphingosine-based lipids are increasingly recognized as active signaling molecules.
  • Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are key examples, derived from phospholipids and sphingolipids, respectively.
  • These lipid mediators are crucial in various signal transduction pathways.

Purpose of the Study:

  • To review recent achievements in the field of bioactive lipids.
  • To discuss the roles of lipid degradation products in cellular signaling.
  • To highlight the involvement of G protein-coupled receptors in mediating lipid mediator actions.

Main Methods:

  • Literature review of recent studies on bioactive lipids.
  • Analysis of signaling pathways involving lipid mediators.
  • Discussion of G protein-coupled receptor characterization relevant to lipid signaling.

Main Results:

  • Numerous lipid degradation products, including LPA and S1P, are potent bioactive molecules.
  • These molecules exert their effects through specific G protein-coupled receptors.
  • Recent research has significantly advanced the understanding of these lipid mediators and their receptors.

Conclusions:

  • Bioactive lipids and their degradation products are critical regulators of cellular processes.
  • The identification and characterization of their cognate receptors have opened new avenues for research.
  • Further investigation into bioactive lipids promises to yield significant insights into cell signaling and disease.

Related Experiment Videos