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Infective endocarditis caused by unusual gram-positive pathogens
J Benes1, D Pícha, M Kabelková
1Department of Infectious Diseases, 3rd Medical Faculty, Charles University, 100 00 Prague, Czechia. benesj@cesnet.cz
Folia Microbiologica
|March 13, 2003
Summary
This study identified rare Gram-positive pathogens causing infectious endocarditis, including Streptococcus pyogenes and Corynebacterium diphtheriae. Early diagnosis and treatment, including antibiotics and surgery, are crucial for patient outcomes.
Area of Science:
- Infectious Diseases
- Cardiology
- Microbiology
Background:
- Infectious endocarditis is a serious infection of the heart lining.
- Gram-positive pathogens are common causes of endocarditis.
Observation:
- A 10-year study (1990-2000) analyzed 81 patients with Gram-positive infectious endocarditis.
- Unusual etiological agents were identified in several cases.
Findings:
- Identified pathogens included Streptococcus pyogenes, Streptococcus pneumoniae, Corynebacterium diphtheriae, and Gemella morbillorum.
- Two patients with cardiac defects (bicuspid aortic valve, tetralogy of Fallot) had unusual agents.
- Successful treatment involved antibiotics alone or with surgery.
- One patient with Corynebacterium diphtheriae died from sepsis and organ failure.
Implications:
- Highlights the importance of considering rare pathogens in infectious endocarditis diagnosis.
- Emphasizes the role of cardiac defects in disease presentation and outcomes.
- Underscores the need for prompt and appropriate antimicrobial and surgical interventions.