Cutaneous metastasis: a meta-analysis of data

Area of Science:

• Oncology
• Dermatology
• Pathology

Background:

• Previous studies lacked consensus on cutaneous metastasis incidence and causes.
• Data from retrospective studies, patient registries, and autopsies were compiled for analysis.

Purpose of the Study:

• To determine the true incidence of cutaneous metastasis.
• To identify the most common primary tumors causing skin metastasis.
• To ascertain the most frequent locations of cutaneous metastatic lesions.

Main Methods:

• A comprehensive meta-analysis was conducted.
• Data were aggregated from patient tumor registries and autopsic studies.

Main Results:

• The overall incidence of cutaneous metastasis was found to be 5.3%.
• Breast cancer was identified as the most common primary tumor metastasizing to the skin.
• The chest emerged as the most frequent site for cutaneous metastasis.

Conclusions:

• This meta-analysis provides a robust overview of cutaneous metastasis incidence and characteristics.
• Findings enhance understanding beyond previous limited analyses.
• Clinical suspicion for firm papulonodules, particularly on the chest, is recommended for early detection.