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Related Experiment Videos

Quantitative GLC determination of codeine in plasma.

R A Zweidinger, F M Weinberg, R W Handy

    Journal of Pharmaceutical Sciences
    |March 1, 1976
    PubMed
    Summary
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    A new gas-liquid chromatography (GLC) method accurately measures codeine in plasma. This sensitive technique can detect codeine at levels as low as 5 ng/ml.

    Area of Science:

    • Analytical Chemistry
    • Pharmacology

    Background:

    • Accurate quantification of codeine in biological matrices is crucial for pharmacokinetic and toxicological studies.
    • Existing methods may lack the sensitivity required for detecting low therapeutic or toxic concentrations.

    Purpose of the Study:

    • To develop and validate a sensitive and accurate gas-liquid chromatography (GLC) method for quantifying codeine in human plasma.

    Main Methods:

    • Gas-liquid chromatography (GLC) was employed for the analysis of codeine.
    • Plasma samples were prepared and analyzed using the developed GLC method.

    Main Results:

    • The method demonstrated high sensitivity, with a limit of detection (LOD) as low as 5 ng/ml.
    • Accurate quantification of codeine was achieved at concentrations of 50 ng/ml and above.

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    Conclusions:

    • The described GLC method provides a reliable tool for the precise measurement of codeine in plasma.
    • This assay is suitable for pharmacokinetic studies and therapeutic drug monitoring.