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The myogenic response in uremic hypertension
David I New1, Alistair M S Chesser, Martin J Raftery
1Anthony Raine Research Laboratories, St. Bartholomew's Hospital, London, England, United Kingdom. dnew@sghms.ac.uk
Kidney International
|March 13, 2003
Summary
Increased myogenic tone does not cause uremic hypertension. Researchers found that resistance arteries in uremic rats did not show increased myogenic constriction, suggesting this mechanism is not responsible for high blood pressure in uremia.
Area of Science:
- Cardiovascular Physiology
- Renal Hypertension
Background:
- The myogenic response of resistance arteries is crucial for regulating peripheral vascular resistance and blood pressure.
- Uremic hypertension is characterized by elevated peripheral resistance, prompting investigation into potential myogenic dysfunction.
Purpose of the Study:
- To evaluate the myogenic response in resistance arteries from a rat model of uremic hypertension.
- To determine if abnormal myogenic constriction contributes to the elevated peripheral resistance observed in uremia.
Main Methods:
- Utilized a pressure myograph to assess myogenic constriction in skeletal muscle arteries from uremic (WKYU) and control (WKYC, SHRC) rats.
- Measured active and passive arterial diameters across a range of pressures (20-200 mm Hg) to quantify the myogenic response.
Main Results:
- Myogenic constriction was comparable between uremic rats (WKYU) and normotensive controls (WKYC) at pressures up to 180 mm Hg.
- Spontaneously hypertensive rats (SHRC) also did not exhibit increased myogenic constriction compared to normotensive controls.
Conclusions:
- Elevated myogenic tone is not the underlying cause of uremic hypertension.
- The study suggests that other mechanisms are responsible for the increased peripheral vascular resistance in uremia.