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C-reactive protein is associated with renal function abnormalities in a non-diabetic population
Erik M Stuveling1, Hans L Hillege, Stephan J L Bakker
1Internal Medicine, Trial Coordination Center, Department of Cardiology/Thoraxcenter, University Hospital Groningen, and Clinical Pharmacology, University of Groningen, Groningen, The Netherlands. e.m.stuveling@int.azg.nl
Kidney International
|March 13, 2003
Summary
C-reactive protein (CRP) predicts cardiovascular events and is linked to kidney function decline. This study found elevated CRP is associated with diminished renal filtration and potentially hyperfiltration, suggesting inflammation
Area of Science:
- Nephrology
- Cardiology
- Inflammation Research
Background:
- C-reactive protein (CRP) is a known predictor of cardiovascular diseases.
- Its role in renal function is less understood.
- This study investigates the association between CRP and kidney function abnormalities.
Purpose of the Study:
- To examine the relationship between C-reactive protein (CRP) levels and renal function loss.
- To assess CRP's association with diminished creatinine clearance and hyperfiltration.
- To identify confounding factors in the CRP-renal function association.
Main Methods:
- A large non-diabetic population (7317 subjects) was studied.
- Creatinine clearance was used to measure renal function (diminished filtration and hyperfiltration).
- CRP levels were analyzed in quartiles, with adjustments for established renal risk factors.
Main Results:
- Elevated CRP levels correlated with cardiovascular and renal risk factors.
- CRP was positively associated with diminished renal filtration (OR 1.8).
- CRP was also associated with hyperfiltration (OR 1.7), largely explained by body mass index.
Conclusions:
- C-reactive protein (CRP) is a risk marker for renal function loss, similar to its role in cardiovascular disease.
- The independent association of CRP with diminished filtration suggests a role in kidney disease progression.
- The link between CRP, body weight, and hyperfiltration suggests inflammation's potential role in early kidney damage.