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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

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Published on: January 28, 2020

Grade of chronic renal failure, and acute and long-term outcome after percutaneous coronary interventions

Holger Reinecke1, Torsten Trey, Fritz Matzkies

  • 1Department of Cardiology and Angiology, Medizinische Klinik und Poliklinik C, University Hospital Münster, Münster, Germany. reinech@uni-muenster.de

Kidney International
|March 13, 2003
PubMed

Insights

Mildly elevated creatinine levels (1.3-1.4 mg/dL) significantly increase mortality risk after percutaneous coronary intervention (PCI). Even slight renal impairment poses a substantial threat to long-term survival in PCI patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Clinical Outcomes

Background:

  • Moderate chronic renal failure increases mortality post-percutaneous coronary intervention (PCI).
  • This study investigates PCI outcomes in patients with mildly elevated creatinine (1.1-1.5 mg/dL).

Purpose of the Study:

  • To assess the impact of mildly elevated serum creatinine on long-term outcomes after PCI.
  • To determine the risk associated with creatinine levels between 1.1 and 1.5 mg/dL in PCI patients.

Main Methods:

  • Retrospective analysis of 1049 PCI patients from 1998-1999.
  • Long-term follow-up (1184 days) achieved with 99.6% completeness via questionnaires.
  • Statistical analysis including Kaplan-Meier and logistic regression models.

Main Results:

  • Mortality increased with creatinine increments above 1.0 mg/dL, significantly at 1.3 mg/dL (12.4% vs. 5.5%).
  • Patients with creatinine 1.3-1.4 mg/dL had lower 3-year survival (87%) vs. controls (96%).
  • Higher creatinine significantly associated with death (OR 2.122).

Conclusions:

  • Mild chronic renal failure (creatinine 1.3-1.4 mg/dL) significantly reduces long-term outcomes post-PCI.
  • Elevated creatinine levels, even mildly, indicate a markedly increased risk for PCI patients.
  • Findings have implications for a large patient population undergoing PCI.
Abstract

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