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Related Experiment Videos

Tissue engineering the kidney.

Marc R Hammerman1

  • 1George M. O'Brien Kidney and Urological Disease Center, Renal Division, Department of Medicine, Washington University School of Medicine, St. Louis Missouri 63310, USA. mhammerm@im.wustl.edu

Kidney International
|March 13, 2003
PubMed
Summary
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Tissue engineering offers promising kidney replacement therapies beyond dialysis and transplantation. Research explores integrating new nephrons, in situ kidney growth, stem cells, nuclear transplantation, and artificial kidneys for improved renal function.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Nephrology

Background:

  • Current kidney replacement therapies like dialysis and allotransplantation have limitations.
  • Dialysis can be poorly tolerated, and kidney transplantation faces donor organ scarcity.

Purpose of the Study:

  • To review progress in tissue engineering strategies for kidney function replacement.
  • To explore methods aiming to restore filtration, reabsorption, secretion, and endocrine/metabolic activities of the kidney.

Main Methods:

  • Review of five distinct tissue engineering approaches.
  • Analysis of cellular therapy and transplantation in four approaches.
  • Evaluation of bioengineered artificial kidney using dialysis.

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Main Results:

  • Progress in integrating new nephrons, growing kidneys in situ, and utilizing stem cells.
  • Advancements in generating histocompatible tissues via nuclear transplantation.
  • Development of bioengineered artificial kidneys as a fifth approach.

Conclusions:

  • Tissue engineering presents multiple avenues for kidney function restoration.
  • All reviewed approaches incorporate cellular therapy, with most also employing transplantation.