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Very slow activity fluctuations in monkey visual cortex: implications for functional brain imaging.

David A Leopold1, Yusuke Murayama, Nikos K Logothetis

  • 1Max Planck Institut für biologische Kybernetik, Spemannstrasse 38, 72076 Tübingen, Germany. david.leopold@tuebingen.mpg.de

Cerebral Cortex (New York, N.Y. : 1991)
|March 13, 2003
PubMed
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Widespread brain activity fluctuations, measured by band-limited power (BLP) of local field potential (LFP) signals, show high coherence across the visual cortex in monkeys. These coherent signals persist across different behavioral states and long timescales, aiding functional magnetic resonance imaging (fMRI) comparisons.

Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Cognitive Neuroscience

Background:

  • Local field potential (LFP) signals reflect neural activity but their long-timescale fluctuations and coherence are not fully understood.
  • Functional magnetic resonance imaging (fMRI) measures blood-oxygen-level-dependent (BOLD) signals, which exhibit high variability, potentially linked to underlying neural activity.
  • Investigating the relationship between LFP and fMRI signals requires understanding coherent neural activity over extended periods.

Purpose of the Study:

  • To examine fluctuations in band-limited power (BLP) of LFP signals in the monkey visual cortex.
  • To determine if these BLP signals exhibit coherent fluctuations over seconds and minutes.
  • To assess the suitability of BLP signals for direct comparison with functional magnetic resonance imaging (fMRI) data.

Related Experiment Videos

Main Methods:

  • Recorded local field potential (LFP) signals from multiple electrodes in the visual cortex of awake monkeys.
  • Analyzed band-limited power (BLP) fluctuations, focusing on very low frequencies (<0.1 Hz) and the gamma frequency range.
  • Quantified coherence of BLP signals between electrode pairs as a function of cortical distance and across different behavioral states.

Main Results:

  • Band-limited power (BLP) of LFP signals showed large-amplitude fluctuations at very low frequencies (<0.1 Hz).
  • BLP signals, particularly in the gamma frequency range, exhibited high coherence between electrode pairs.
  • BLP coherence was maintained over longer cortical distances and was similar across different behavioral states, unlike raw LFP coherence.

Conclusions:

  • Demonstrated widespread, coherent activity fluctuations in the awake monkey brain over long timescales (seconds to minutes).
  • Propose that these coherent BLP fluctuations contribute significantly to the variability observed in physiological signals, including fMRI.
  • Suggest that BLP signals are suitable candidates for combined fMRI and electrophysiological recordings due to their widespread coherence.