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This study compared ferrous sulfate alone versus ferrous sulfate with folic acid in pregnant women. No significant differences in obstetric complications were observed between the two groups.

Area of Science:

Obstetrics and Gynecology
Nutritional Science
Clinical Trials

Background:

Iron deficiency anemia is common in pregnancy.
Folic acid supplementation is recommended during pregnancy.
The combined effect of ferrous sulfate and folic acid on obstetric outcomes requires further investigation.

Purpose of the Study:

To compare the effects of ferrous sulfate alone versus ferrous sulfate plus folic acid on obstetric complications in pregnant women.

Main Methods:

A controlled, prospective trial was conducted.
76 pregnant women received ferrous sulfate 50 mg daily.
82 pregnant women received ferrous sulfate 50 mg daily plus folic acid 0.5 mg daily.
Data were collected from 12 general practices in South-east England.

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Main Results:

No significant differences in obstetric complications were found between the group receiving ferrous sulfate alone and the group receiving ferrous sulfate plus folic acid.
The study may have been underpowered to detect rare complications.

Conclusions:

Ferrous sulfate alone and ferrous sulfate plus folic acid appear to have similar effects on obstetric complications in this patient population.
Further research with larger sample sizes may be needed to confirm these findings and investigate rare complications.