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Oxidative stress and hemorheological changes induced by acute treadmill exercise
Ranjeet S Ajmani1, Jerome L Fleg, A Andrew Demehin
1National Institute on Aging, National Institutes of Health, Molecular Dynamics Section and the Laboratory of Cardiovascular Sciences, Baltimore, MD 21224, USA. ranjeet_ajmani@intaspharma.com
Clinical Hemorheology and Microcirculation
|March 13, 2003
Summary
Acute aerobic exercise increases oxidative stress and negatively impacts blood flow properties. This study found exercise-induced damage to red blood cells and altered blood viscosity in healthy adults.
Area of Science:
- Exercise Physiology
- Blood Rheology
- Oxidative Stress
Background:
- Aerobic exercise is widely recommended for health.
- The acute effects of intense exercise on blood properties require further elucidation.
Purpose of the Study:
- To investigate the immediate impact of maximal aerobic exercise on oxidative stress markers.
- To assess changes in blood rheological properties following acute aerobic exercise.
Main Methods:
- Fourteen healthy adults (7 men, 7 women) performed maximal treadmill exercise.
- Blood samples were collected pre- and post-exercise for analysis.
- Measurements included plasma lipid hydroperoxides, fluorescent products, hematocrit, and blood viscosity.
Main Results:
- Significant increases in plasma lipid hydroperoxides and red cell peroxidation products were observed post-exercise.
- Hematocrit and whole blood viscosity (at various shear rates) increased significantly.
- Plasma viscosity rose, red cell rigidity increased, and erythrocyte sedimentation rate decreased.
Conclusions:
- Acute aerobic exercise induces oxidative damage to red blood cells.
- Exercise adversely affects the rheological properties of peripheral blood.