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Intracranial plasma cell granuloma with genetic analysis
M Murakami1, N Hashimoto, S Kimura
1Department of Neurosurgery, Kyoto First Red Cross Hospital, and Kyoto Prefectural University of Medicine, Kajii-cho 465, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
Acta Neurochirurgica
|March 13, 2003
Summary
Central nervous system plasma cell granuloma is rare. Genetic analysis aids in diagnosing this condition, with no recurrence observed in a recent case after surgical removal.
Area of Science:
- Neuropathology
- Oncology
Background:
- Plasma cell granuloma (PCG) of the central nervous system (CNS) is an exceptionally rare entity, with fewer than 30 cases documented globally.
- Distinguishing PCG from neoplastic lesions in the CNS can be challenging based on clinical and imaging findings alone.
Observation:
- A 64-year-old female presented with headaches, and neuroimaging revealed a parasagittal brain tumor, initially suspected to be a meningioma.
- Surgical resection was performed, and subsequent pathological examination confirmed the diagnosis of plasma cell granuloma.
Findings:
- Polymerase chain reaction (PCR) analysis for immunoglobulin heavy chain (IgH) gene rearrangements did not detect a monoclonal band, suggesting a non-neoplastic, possibly reactive, process.
- The patient experienced no tumor recurrence in the 3 years following complete surgical resection, without requiring further treatment.
Implications:
- This case highlights the importance of integrating histopathological findings with molecular analyses, such as PCR for clonality assessment, in diagnosing CNS plasma cell granuloma.
- Accurate diagnosis through genetic analysis supports appropriate clinical management and prognosis for this rare CNS condition.