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[The yellow nail syndrome].

M Riedel1, V Bohanes

  • 1Deutsches Herzzentrum, Technische Universität München. m.riedel@dhm.mhn.de

Pneumologie (Stuttgart, Germany)
|March 13, 2003
PubMed
Summary
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Yellow Nail Syndrome, characterized by nail changes and fluid buildup, can present with diverse symptoms like pleural effusions and lymphoedema. This case highlights its generally benign progression over a decade.

Area of Science:

  • Medicine
  • Pulmonology
  • Genetics

Background:

  • Yellow Nail Syndrome (YNS) is a rare disorder characterized by distinct nail changes, lymphedema, and respiratory issues.
  • The exact etiology of YNS remains unknown, but impaired lymphatic drainage is implicated in its pathogenesis.

Observation:

  • A 54-year-old woman presented with classic Yellow Nail Syndrome, including yellowing nails, exudative pleural effusions, lymphoedema, pericardial effusion, rhinosinusitis, and bronchiectasis.
  • The patient experienced a relatively benign clinical course over a ten-year period, demonstrating the potential for long-term stability.

Findings:

  • The case underscores the varied clinical manifestations of YNS, emphasizing the need for broader diagnostic consideration.
  • Literature review suggests YNS may be underdiagnosed due to its diverse presentations and potentially indolent nature.

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Implications:

  • YNS should be included in the differential diagnosis for patients presenting with bilateral pleural effusions.
  • Increased awareness of YNS's spectrum of symptoms may lead to earlier and more frequent diagnoses, improving patient management.